-2.png)
Kalman Tiboldi - CTO & Founder at GemOne-TVH - Simplify or Die: Why Complexity Is the Real IT Challenge
-2.png)
Germany Aug 27, 2025 Country Members Virtual german
Die neuen geo-politischen Veränderungen und unvorhergesehene wirtschaftliche Anforderungen stellen Digital Leader vor neue Herausforderungen. Immer öfter wird in den Vorstandsetagen die Frage gestellt, wie der (IT) Betrieb sicher und ungestört weiter funktionieren kann, wenn regionale Rechenzentren und Infrastrukturen plötzlich nicht mehr verfügbar oder nur teilweise noch einsatzbereit sind. Der CIO muss für diese neue Welt resiliente Strategien parat haben, die für Business Continuity in bisher nicht vorstellbaren politischen und wirtschaftlichen Szenarien ermöglichen.
Read More
Belgium Aug 28, 2025 Country Members Physical english
With the theme “The Power of Connection,” we’re embracing the essence of meaningful connections within IT and beyond. To honour our tradition, expect an unforgettable evening featuring keynote presentations, open bars, a summer BBQ, and a special experience designed to bring our vibrant community together.
Read More
Belgium Aug 28, 2025 Country Members Physical english
A special celebration marking 20 years of CIONET—two decades of empowering digital leaders and driving innovation in the technology landscape. This exclusive event will bring together our members to reflect on the incredible journey we've shared and look ahead to the future of digital leadership.Featuring keynote presentations from visionary CIOs, industry pioneers, and founding members, we’ll explore how far we’ve come and what lies ahead in the ever-evolving world of technology. Together, we will honour the contributions of our members who have shaped CIONET’s legacy while offering insights into how the community will continue to lead in the years to come.This is more than a celebration—it’s an opportunity to reconnect, reflect, and recharge with your fellow digital leaders. Don't miss this exclusive experience packed with inspiring talks, networking opportunities, and special recognitions that highlight the best of CIONET’s history and future.Let’s celebrate the past, present, and future of the digital community you helped build.
Read More.png)
-1.png)
Germany Sep 9, 2025 Country Members Physical german
Vom ersten Use Case zur strategischen Neuausrichtung CIONET lädt bereits zum vierten Mal zu einem exklusiven Roundtable für CIOs und Digitalverantwortliche aus Logistik und Handel ein. Im Mittelpunkt des Abends steht die Frage, wie Unternehmen ihre KI-Initiativen erfolgreich skalieren und aus ersten Use Cases echten strategischen Mehrwert schaffen. Microsoft 365 für Frontline Worker: Moderne Tools, die Mitarbeitende im Tagesgeschäft entlasten ServiceNow für Prozessintegration: Automatisierte End-to-End-Workflows – vom Schadensfall bis zur Retourenabwicklung KI-gestützte Disposition und Planung: Mit smarten Algorithmen zur optimierten Supply Chain Digitale Lieferketten und letzte Meile: Transparenz, Effizienz und Kundenzentrierung durchgängig gedacht
Read More
Belgium Sep 13, 2025 All Members Physical english
Join us for a wonderful ride. The ride is accessible to all levels of riders and doesn't require extensive technical skills. More information will follow soon. Looking forward to ride together!
Read More
Exscientia Uses Generative AI to Reimagine Drug Discovery
Exscientia uses generative artificial intelligence (AI) throughout the design-make-test-learn (DMTL) cycle to discover new therapies for patients quickly and relatively inexpensively.
“Using AWS, we reduce bottlenecks and accelerate the pipeline.”
David Hallett
Interim CEO and Chief Scientific Officer, Exscientia
Exscientia uses generative artificial intelligence (AI) throughout the design-make-test-learn (DMTL) cycle to discover new therapies for patients quickly and relatively inexpensively. Conventional drug discovery methods can take up to 15 years and cost over 2 billion dollars, with an average failure rate of 90–96 percent because scientists hunt for specific drug candidates among 1060 bioavailable small molecules.
Built on Amazon Web Services (AWS), Exscientia’s innovative DMTL solution incorporates in silico design—using generative AI algorithms to design compounds in the cloud—and automated robots that make drug candidates in a lab. “We use generative AI to solve for efficiency and effectiveness,” says David Hallett, Exscientia’s interim CEO and chief scientific officer. “By predicting the molecular features of a safe and effective drug in silico, we minimize the number of costly experiments. Our platform, built in collaboration with the AWS team, is optimized for speed. We can repeat many DMTL learning loops, improving our drug candidates with every iteration.”
Working backward from patient needs, Exscientia defines precise target product profiles (TPPs) that specify the complex combination of properties required by a well-tolerated and effective medicine. AI engineers design algorithms that generate panels of potential drug candidates to meet the TPPs. Active learning algorithms help expert designers to select a short list of drug candidates to synthesize in the lab, because they either move the TPPs forward or refine the models for future DMTL cycles.
Exscientia’s algorithms are trained on publicly available pharmacology data and proprietary in-house data generated from patient tissue samples, genomics, single-cell transcriptomics, and medical literature. By encoding data throughout the process and analyzing experimental results and previous design cycles, Exscientia can optimize upcoming design cycles and promote compound designs that are physically synthesizable. Using this synthesis-aware, iterative approach built on AWS, Exscientia makes 10 times fewer compounds than the industry average. “The idea is to iron out chemical liabilities to make safer and more effective drug candidates before we ever test them in patients,” says Hallett.
Exscientia has accelerated drug design by up to 70 percent while decreasing capital cost by 80 percent, compared with industry benchmarks. Using generative AI with other tools, Exscientia not only developed better drug candidates faster but also identified the right drug combinations to trial with patients in the clinic.
Exscientia has incorporated cutting-edge chemistry synthesis and biology assay lab equipment with automation robots to avoid manual handling of lab equipment. Thus, its lab—orchestrated by AWS microservices—can operate 24/7 with minimal human supervision, “When our designs are ready, we can push a button, and within a few days, the robots are making the drug,” says Hallett. Maintaining extremely high levels of security and comprehensive disaster recovery, Exscientia will use this automated robotic capability to reduce the make and test timelines resulting from traditional offshore research contracts used across the industry.
As the company closes the loop with its robotic automation lab, it expects further productivity improvements. Data generated in the lab improves algorithmic predictions and speeds up DMTL cycles.
Six molecules that Exscientia designed using AI have entered clinical trials. “Using AWS, we reduce bottlenecks and accelerate the pipeline,” says Hallett. “By switching on this highly integrated and automated DMTL loop, we can make drug candidates faster and more cost-effective.”
Kalman Tiboldi - CTO & Founder at GemOne-TVH - Simplify or Die: Why Complexity Is the Real IT Challenge
.png)
Isabelle Droll - CIO for Airline, Corporate, Hotels & Resorts and Sustainability at TUI - Data, Diversity, and Destinations
.png)
Sharon Prior - CIO in transition - How Great Tech Leadership Begins with Business Thinking
-1.jpg)
José Antonio López, Group CIO at TOUS - Jewels, Data & AI: Inside the Digital Transformation of TOUS
.png)
Tom Tanghe - General Manager ITC EMEA at Daikin Europe - Reinventing the CIO Role
.jpg)
CIOFEST 2025 - From Order Taker to Proactive Disruptor
Geopolitical tensions have dominated the headlines for over two years now. In this context, the cyber threat landscape is also evolving rapidly. The protection and security of critical infrastructure – both physical and digital – is becoming increasingly important.
.png?width=600&height=600&name=Anna%20Kopp%20(1).png)
